Background: Staff satisfaction, organizational effectiveness, and the standard of patient care are all directly impacted by workforce retention and burnout, which are major issues in the healthcare industry. High turnover rates, higher expenses, and worse healthcare results are all consequences of burnout, a condition marked by emotional tiredness, depersonalization, and decreased personal accomplishment. Maintaining an efficient and robust healthcare workforce requires an understanding of and commitment to tackling these concerns. Aim: this study is to examine the intricate connection between burnout and staff retention in the healthcare industry, pinpoint important contributing variables, and assess evidence-based tactics for reducing burnout and enhancing retention. Methods: Research on burnout and retention in healthcare settings was the main topic of a comprehensive review of peer-reviewed literature published between 2010 and 2023. Qualitative interviews with medical experts were also examined in order to learn more about organizational procedures and useful interventions. The results of the intervention were evaluated using metrics such validated burnout indexes, staff satisfaction ratings, and attrition rates. Results: The results show that problems including excessive workloads, inadequate staffing, and a lack of organizational support are the main causes of burnout.