Large scale and global environmental hazards to human health are becoming increasingly apparent. These include climate change, stratospheric ozone depletion, loss of biodiversity, changes in hydrological systems, changes in supplies of fresh water, land degradation, and stresses on food producing systems. Appreciation of the effects of these health hazards requires an understanding of ecosystems, their complexity of these systems and how we interact with them. The effects of these changes are not distributed evenly around the world with some area more vulnerable than others, especially among low and middle income countries that are not prepared for potential environmental impacts, and even less for health related impacts. The world€™s climate change is being altered as a consequence of human activity. These are direct impacts, such as temperature-related illness and death including the health impacts of extreme weather events and the effect of air polluting spores and moulds. Other impacts are more indirect and led to water and food borne diseases, vector and rodent borne diseases, or food and water shortage. However, economic sustainable growth should be maintained as long climate change and its impact to health, agriculture, forest, water resource, species and coastal area. Keywords: climate changes, human health, sustainable development.